The 1880 South Carolina gubernatorial election was held on November 2, 1880 to s elect the governor of South Carolina. Johnson Hagood was nominated by the Democrats and ran against L. W. R. Blair, a Greenback-Labor candidate. Hagood easily won the general election and became the 80th governor of South Carolina.

Johnson Hagood was a planter, soldier and military officer in the Confederate States Army during the American Civil War, reaching the rank of brigadier general in the state militia and regular Confederate Army in 1862.