The 1880 season was the first for the Worcester Worcesters franchise in the National League, having played 1879 in the National Association. The team finished its initial season with a 40–43 record, good for fifth place. Lee Richmond threw a perfect game on June 12, 1880, the first ever perfect game in Major League Baseball history in a 1–0 victory over the Cleveland Blues. On August 20, they became the first major-league team to be no-hit at home when Pud Galvin of the Buffalo Bisons defeated them, 1–0.

The following are the baseball events of the year 1880 throughout the world.