The 1882 Louisville Eclipse season was the first season as a Major League club for the franchise. The team, which had played for several years as a semi-pro team, joined the new American Association league. They finished the season with a 42–38 record, good for second place.

The 1882 St. Louis Brown Stockings season was the first professional baseball season played by the team now known as the St. Louis Cardinals. The team was founded in the earlier St. Louis Brown Stockings franchise. It played in the National Association league in 1875 and in the National League from 1876 to 1877. After a scandal over game-fixing, combined with financial problems, the St Louis Brown Stockings left the National League but continued to play as an independent team from 1878 to 1881. Chris von der Ahe, a German immigrant, purchased the team prior to the 1882 season and joined the new American Association. The St. Louis Brown Stockings posted a 37-43 game record in their first season in the American Association, giving them fifth place. The team played at the Grand Avenue Grounds at the corner of Grand Avenue and Dodier Street in north St. Louis.