The 1895 Penn Quakers football team was an American football team that represented the University of Pennsylvania as an independent during the 1895 college football season. In their fourth season under head coach George Washington Woodruff, the Quakers compiled a 14–0 record, shut out 10 of 14 opponents, and outscored all opponents by a total of 480 to 24.

George Washington Woodruff was an American college football player, rower, coach, teacher, lawyer and politician. He served as the head football coach at the University of Pennsylvania (1892–1901), the University of Illinois at Urbana–Champaign (1903), and Carlisle Indian Industrial School (1905), compiling a career college football record of 142–25–2. Woodruff's Penn teams of 1894, 1895, and 1897 have been recognized as national champions. Woodruff was inducted into the College Football Hall of Fame as a coach in 1963.