The 1899 St. Louis Perfectos season was the team's 18th season in St. Louis, Missouri and their eighth season in the National League. The Perfectos went 84–67 during the season and finished fifth in the National League.

The St. Louis Cardinals, a professional baseball franchise based in St. Louis, Missouri, compete in the National League (NL) of Major League Baseball (MLB). As the game of baseball garnered interest in the United States in the 19th century, professional baseball in St. Louis became rooted chiefly in one disestablished Major League club – named the Brown Stockings, the same as the Cardinals' earliest name – which is loosely connected, but does not fall within the scope of, today's Cardinals. The Brown Stockings became St. Louis' first fully professional baseball club when they gained accession in the National Association (NA) in 1875. However, the NA folded after that season. That winter, with five other former NA teams, St. Louis established a new, eight-team league called the National League (NL) and began play the next season. Despite early success, Brown Stocking players were found to be connected to game fixing scandals, which forced bankruptcy and the club's expulsion from the NL. This scandal also abrogated their professional status but some members maintained play as a semi-professional team, primarily operated by outfielder Ned Cuthbert, until 1881.