18th and Vine is a neighborhood of Kansas City, Missouri. It is internationally recognized as a historical point of origin of jazz music and a historic hub of African-American businesses. Along with Basin Street in New Orleans, Beale Street in Memphis, 52nd Street in New York City, and Central Avenue in Los Angeles, the 18th and Vine area fostered a new style of jazz. Kansas City jazz is a riff-based and blues-influenced sound developed in jam sessions in the neighborhood's crowded clubs. Many notable jazz musicians of the 1930s and 1940s lived or got started here, including Charlie Parker. Due to this legacy, U.S. Representative Emanuel Cleaver said 18th and Vine is America's third most recognized street after Broadway and Hollywood Boulevard.

Kansas City, Missouri is the largest city in the U.S. state of Missouri by population and area. Most of the city lies within Jackson County, with portions spilling into Clay, Platte, and Cass counties. It is the central city of the Kansas City metropolitan area, which straddles the Missouri–Kansas state line and has a population of 2,392,035. As of the 2020 census, the city had a population of 508,090, making it the 37th most-populous city in the United States, as well as the sixth-most populous city in the Midwest. Kansas City was founded in the 1830s as a port on the Missouri River at its confluence with the Kansas River from the west. On June 1, 1850, the town of Kansas was incorporated; shortly after came the establishment of the Kansas Territory. Confusion between the two ensued, and the name Kansas City was assigned to distinguish them soon after.