The 1904 Penn Quakers football team was an American football team that represented the University of Pennsylvania as an independent during the 1904 college football season. In their third season under head coach Carl S. Williams, the Quakers compiled a 12–0 record, shut out 11 of 12 opponents, and outscored all opponents by a total of 222 to 4.

The 1904 college football season had no clear-cut champion, with the Official NCAA Division I Football Records Book listing Michigan, Minnesota, and Penn as having been selected national champions.