The 1906 Saint Louis Blue and White football team was an American football team that represented Saint Louis University as an independent during the 1906 college football season. In its first season under head coach Eddie Cochems, the team compiled a perfect 11–0 record and outscored opponents by a total of 407 to 11.

Edward Bulwer Cochems was an American football player and coach. He played football for the University of Wisconsin from 1898 to 1901 and was the head football coach at North Dakota Agricultural College—now known as North Dakota State University (1902–1903), Clemson University (1905), Saint Louis University (1906–1908), and the University of Maine (1914). During his three years at Saint Louis, he was the first football coach to build an offense around the forward pass, which became a legal play in the 1906 college football season. Using the forward pass, Cochems' 1906 team compiled an undefeated 11–0 record, led the nation in scoring, and outscored opponents by a combined score of 407 to 11. He is considered by some to be the "father of the forward pass" in American football.