The 1906 Saint Louis Blue and White football team was an American football team that represented Saint Louis University as an independent during the 1906 college football season. In its first season under head coach Eddie Cochems, the team compiled a perfect 11–0 record and outscored opponents by a total of 407 to 11.

The 1906 college football season was the first in which the forward pass was permitted. Although there was no clear cut national championship, there were two teams that had won all nine of their games as the 1906 season drew to a close, the Princeton Tigers and the Yale Bulldogs, and on November 17, 1906, they played to a 0–0 tie. St. Louis University finished at 11–0–0. The Helms Athletic Foundation, founded in 1936, declared retroactively that Princeton had been the best college football team of 1906. Other selectors recognized Yale as the national champions for 1906.