The 1908 Manchester North West by-election was a Parliamentary by-election held on 24 April 1908. The constituency returned one Member of Parliament (MP) to the House of Commons of the United Kingdom, elected by the first past the post voting system.

Manchester North West was one of six single-member Parliamentary constituencies created in 1885 by the division of the three-member Parliamentary Borough of Manchester under the Redistribution of Seats Act 1885. Its first MP, William Houldsworth, had previously sat for Manchester. It was abolished in 1918.