The 1910 Edinburgh South by-election was a parliamentary by-election held for the House of Commons constituency of Edinburgh South in Scotland on 29 April 1910.

Edinburgh South is a constituency of the House of Commons of the UK Parliament created in 1885. The constituency has been held by Scottish Labour since 1987, being represented by Ian Murray since 2010. Murray was the only Labour MP in Scotland to retain his seat at the 2015 and 2019 general elections and this is one of only three seats never held by the Scottish National Party (SNP).