The 1910 New South Wales state election was held on 14 October 1910 for all of the 90 seats in the 22nd New South Wales Legislative Assembly and it was conducted in single-member constituencies with a second ballot if a majority was not achieved on the first. Both adult males and females were entitled to vote, but not Indigenous people. The 21st parliament of New South Wales was dissolved on 14 September 1910 by the Governor, Lord Chelmsford, on the advice of the Premier Charles Wade.

The premier of New South Wales is the head of government in the state of New South Wales, Australia. The Government of New South Wales follows the Westminster Parliamentary System, with a Parliament of New South Wales acting as the legislature. The premier is appointed by the Governor of New South Wales, and by modern convention holds office by their ability to command the support of a majority of members of the lower house of Parliament, the Legislative Assembly.