State elections were held in South Australia on 2 April 1910. All 42 seats in the South Australian House of Assembly were up for election. The incumbent Liberal and Democratic Union (LDU) government led by Premier of South Australia Archibald Peake was defeated by the United Labor Party (ULP) led by John Verran. Each of the 13 districts elected multiple members, with voters casting multiple votes. The Peake LDU minority government had replaced the Price ULP/LDU coalition government in June 1909. The 1910 election was the first to result in a South Australian majority government. This came two weeks after the election of a first majority in either house in the Parliament of Australia at the 1910 federal election, also for Labor. Though a South Australian majority was won, the ULP did not take office until after the new lower house first met.

The premier of South Australia is the head of government in the state of South Australia, Australia. The Government of South Australia follows the Westminster system, with a Parliament of South Australia acting as the legislature. The premier is appointed by the governor of South Australia, and by modern convention holds office by virtue of their ability to command the support of a majority of members of the lower house of Parliament, the House of Assembly.