The 1915–16 National Challenge Cup was the third tournament of the modern-day Lamar Hunt U.S. Open Cup. Bethlehem Steel won its second consecutive championship. The entries for the competition were to be made by midnight September 30, 1915. The draw for the qualifying and first rounds was made on October 2, 1915. The tournament schedule was originally set for the qualifying round to take place on or before October 24; first round, November 14; second round, December 12; third round, January 16, 1916; fourth round, March 5; semis, April 2, and final on April 30.

Bethlehem Steel Football Club (1907–1930) was one of the most successful early American soccer clubs. Known as the Bethlehem Football Club from 1907 until 1915 when it became the Bethlehem Steel Football Club, the team was sponsored by the Bethlehem Steel corporation. Bethlehem Steel FC played their home games first at East End Field in Bethlehem, Pennsylvania, in the Lehigh Valley, then later on the grounds Bethlehem Steel built on Elizabeth Ave named Bethlehem Steel Athletic Field.