The 6th International 300-Mile Sweepstakes Race was the sixth running of the Indianapolis 500. It was held at the Indianapolis Motor Speedway on Tuesday, May 30, 1916. The management scheduled the race for 120 laps, 300 miles (480 km), the only Indianapolis 500 scheduled for less than 500 miles (800 km).

Dario Raoul Resta, was a British racing driver. He is best remembered for his successes racing Indy cars in the United States. The 1916 American National Champion, Resta was the winner of the 1916 Indianapolis 500, as well as the Vanderbilt Cup in 1915 and 1916.