The 1916 United States Senate election in Indiana took place on November 7, 1916. Incumbent Democratic U.S. Senator and Senate Majority Leader John W. Kern ran for re-election to a second term in office, he was defeated by Republican Harry New, a former Chairman of the Republican National Committee.

John Worth Kern was a Democratic United States Senator from Indiana. While the title was not official, he is considered to be the first Senate majority leader, while serving concurrently as chairman of the Senate Democratic Caucus. He was also the Democratic vice presidential nominee in the 1908 presidential election.