The 1916 United States Senate election in Minnesota took place on November 7, 1916. It was the first election for either class of U.S. senators held in Minnesota after the ratification of the Seventeenth Amendment to the United States Constitution, which established the popular election of United States senators. Incumbent Senator Moses E. Clapp was defeated in the Republican primary election by former American Bar Association president Frank B. Kellogg. Kellogg went on to defeat former St. Paul Mayor Daniel W. Lawler of the Minnesota Democratic Party, and Prohibition Party challenger Willis Greenleaf Calderwood, in the general election.

Frank Billings Kellogg was an American lawyer, politician, and statesman who served in the U.S. Senate and as U.S. Secretary of State. He co-authored the Kellogg–Briand Pact, for which he was awarded the Nobel Peace Prize in 1929.