The 1917 Centre football team represented Centre College in the 1917 college football season and began a string of unparalleled success for the school. The first two games were coached by Robert L. Myers, and the rest by Charley Moran. According to Centre publications, "Myers realized he was dealing with a group of exceptional athletes, who were far beyond his ability to coach. He needed someone who could the team justice, and found that person in Charles Moran."

The 1917 college football season ended with six undefeated teams in Georgia Tech, Pittsburgh, Ohio State, Texas A&M, Williams, and Washington State.