The 1919 Centre Praying Colonels football team represented Centre College in the 1919 Southern Intercollegiate Athletic Association football season. The Praying Colonels scored 485 points, leading the nation, while allowing 23 points and finishing their season with a perfect record of 9–0. The team was retroactively selected by Jeff Sagarin as national champion for the 1919 season.

Alvin Nugent "Bo" McMillin was an American football player and coach at the collegiate and professional level. He played college football at Centre College in Danville, Kentucky, where he was a three-time All-American at quarterback, and led the Centre Praying Colonels to an upset victory over Harvard in 1921. McMillin was inducted into the College Football Hall of Fame as a player as part of its inaugural 1951 class.