The 1921 College Football All-America team is composed of college football players who were selected as All-Americans by various organizations and writers that chose College Football All-America Teams in 1921. The only selector recognized by the NCAA as "official" for the 1921 season is Walter Camp, whose selections were published in Collier's Weekly. Additional selectors who chose All-American teams in 1921 included: Football World magazine, based on collected opinions of 267 coaches; Walter Eckersall of the Chicago Tribune; Jack Veiock, sports editor of the International News Service; and Norman E. Brown of the Central Press Association.

Aubrey Alvin "Aub" Devine was an American football and basketball player, coach, and lawyer. He was the quarterback for the University of Iowa Hawkeyes football team from 1919 to 1921. He was selected as a first-team All-Big Ten Conference player all three years at Iowa and was the consensus All-American quarterback in 1921. Devine served as the head basketball coach at the University of Denver for two seasons, from 1923 to 1925. He later worked as an assistant football coach under Howard Jones at the University of Southern California (USC). Devine was inducted into the College Football Hall of Fame as a player in 1973.