The 1921 Vanderbilt Commodores baseball team represented the Vanderbilt Commodores of Vanderbilt University in the 1921 NCAA baseball season, winning the SIAA championship. By May 29, the team had hit over .225 for the season, garnering 27 home runs, 17 triples, 26 doubles, 107 singles, and a total of 138 hits for 326 bases with 54 stolen bases.

The Vanderbilt Commodores baseball team is an American National Collegiate Athletic Association (NCAA) college baseball team from Vanderbilt University in Nashville, Tennessee. The team participates in the Eastern division of the Southeastern Conference (SEC) and plays its home games on campus at Hawkins Field. The Commodores are coached by three-time National Coach of the Year and three-time SEC Coach of the Year, Tim Corbin. During Corbin's tenure as head coach, Vanderbilt has become one of the premier college baseball programs in the United States, responsible for 19 first-round picks in the MLB draft.