The 1922 Newport by-election was by-election held in the parliamentary constituency of Newport in Wales on 18 October 1922. The by-election attracted especial attention, both at the time and since, as it was seen as a crucial electoral test of the viability of the Lloyd George Coalition Government, formed of followers of David Lloyd George with the Conservative Party, the latter of which contained an increasing number of members who wished to leave the coalition and regain the party's independence.

Newport was a borough constituency in Monmouthshire from 1918 to 1983. It returned one Member of Parliament (MP) to the House of Commons of the Parliament of the United Kingdom, elected by the first past the post system.