The 1922 United States Senate election in Montana took place on November 7, 1922. Incumbent United States Senator Henry L. Myers, who was first elected to the Senate in 1910, and was re-elected in 1916, declined to seek re-election. Former United States Attorney Burton K. Wheeler won the Democratic primary and advanced to the general election, where he faced Carl W. Riddick, the United States Congressman from Montana's 2nd congressional district and the Republican nominee. Ultimately, Wheeler defeated Riddick comfortably and won his first term in the Senate.

Burton Kendall Wheeler was an attorney and an American politician of the Democratic Party in Montana, which he represented as a United States senator from 1923 until 1947.