The 1922 Vanderbilt Commodores football team represented Vanderbilt University during the 1922 Southern Conference football season. During the season, Dan McGugin's 18th as head coach, Vanderbilt compiled a record of 8–0–1 and outscored its opponents 177 to 16. The Commodores' defense was unrivaled in the South, leading the nation in giving up just 1.8 points per game, none of them at home. The season included a tie with Michigan at the dedication of the new Dudley Field; the first stadium in the South to be used exclusively for college football. The season was immediately dubbed one of the best in Vanderbilt and Southern football history.

Daniel Earle McGugin was an American college football player and coach, as well as a lawyer. He served as the head football coach at Vanderbilt University in Nashville, Tennessee from 1904 to 1917 and again from 1919 to 1934, compiling a record of 197–55–19. He is the winningest head coach in the history of the university. McGugin was inducted into the College Football Hall of Fame as a coach in 1951 as part of its inaugural class. He was the brother-in-law of University of Michigan coach Fielding H. Yost.