The 1925 Pittsburgh Panthers football team was an American football team that represented the University of Pittsburgh as an independent during the 1925 college football season. In its second season under head coach Jock Sutherland, the team compiled an 8–1 record and outscored opponents by a total of 151 to 34. The team was ranked No. 10 in the nation in the Dickinson System ratings released in January 1926. This was the Panthers' first season at Pitt Stadium, and the team played eight of its nine games there.

The 1925 college football season ended with no clear national champion. At the close of the season, noted sports writer Billy Evans described the championship contest as "a dead heat" among Dartmouth, Tulane, Michigan, Washington, and Alabama.