The 1927 College Football All-Southern Team consists of American football players selected to the College Football All-Southern Teams selected by various organizations in for the 1927 Southern Conference football season.

William Douglas Spears, known as "Bounding Bill Spears", was an American football player and stand-out quarterback for Dan McGugin's Vanderbilt Commodores football teams from 1925 to 1927. Spears was elected to the College Football Hall of Fame in 1962. Grantland Rice said of Spears that he was one of the fastest quarters he had ever seen.