The 16th International 500-Mile Sweepstakes Race was held at the Indianapolis Motor Speedway on Wednesday, May 30, 1928. This was the first Indianapolis 500 presided over by new Speedway president Eddie Rickenbacker. Rain threatened to wash out the day, but the showers stopped and the race started on time. One brief shower slowed the race around the 400-mile mark, bringing out the yellow flag for a few laps.

Louis Meyer was an American racing driver who was the first three-time winner of the Indianapolis 500. He is generally regarded as one of the finest racers of his generation. Meyer is perhaps best known as the driver who started the tradition of drinking milk after winning the Indianapolis 500.