The 1941 Duke Blue Devils football team was an American football team that represented Duke University as a member of the Southern Conference during the 1941 college football season. In their 11th season under head coach Wallace Wade, the Blue Devils compiled a 9–0 record during the regular season, won the Southern Conference championship, and outscored opponents by a total of 311 to 41. Ranked No. 2 in the final AP Poll, the Blue Devils were invited to play in the 1942 Rose Bowl, losing to Oregon State by a 20–16 score.

William Wallace Wade was an American football player and coach of football, basketball, and baseball, and college athletics administrator. He served as the head football coach at the University of Alabama from 1923 to 1930 and at Duke University from 1931 to 1941 and again from 1946 to 1950, compiling a career college football record of 171–49–10. His tenure at Duke was interrupted by military service during World War II. Wade's Alabama Crimson Tide football teams of 1925, 1926, and 1930 have been recognized as national champions, while his 1938 Duke team had an unscored upon regular season, giving up its only points in the final minute of the 1939 Rose Bowl. Wade won a total of ten Southern Conference football titles, four with Alabama and six with the Duke Blue Devils. He coached in five Rose Bowls including the 1942 game, which was relocated from Pasadena, California to Durham, North Carolina after the attack on Pearl Harbor.