The 1942 United States Senate elections were held November 3, 1942, midway through Franklin D. Roosevelt's third term as president. The 32 seats of Class 2 were contested in regular elections, and two special elections were held to fill vacancies.

Matthew Mansfield Neely was an American Democratic politician from West Virginia. He is the only West Virginian to serve in both houses of the United States Congress and as the Governor of West Virginia. He is also the only person to have held a full term in both Senate seats from the state.