The 1950 Grand Prix motorcycle racing season was the second F.I.M. Road Racing World Championship Grand Prix season. The season consisted of six Grand Prix races in five classes: 500cc, 350cc, 250cc, 125cc and Sidecars 600cc. It began on 10 June, with Isle of Man TT and ended with Nations Grand Prix on 10 September.

The Isle of Man TT or Tourist Trophy races are an annual motorcycle racing event run on the Isle of Man in May and June of most years since its inaugural race in 1907. The event begins on the UK Spring Bank Holiday at the end of May and runs for thirteen days. It is often called one of the most dangerous racing events in the world as many competitors have died.