The 1952 United States Senate elections was an election for the United States Senate which coincided with the election of Dwight D. Eisenhower to the presidency by a large margin. The 32 Senate seats of Class 1 were contested in regular elections, and three special elections were held to fill vacancies. The Republicans took control of the Senate by managing to make a net gain of two seats. However, Wayne Morse (R-OR) became an independent forcing Republicans to rely on Vice President Richard Nixon's tie-breaking vote, although Republicans maintained a 48–47–1 plurality. Throughout the next Congress, Republicans were able to restore their 49–46–1 majority. This was the third time, as well as second consecutive, in which a sitting Senate leader lost his seat.

The 1950 United States Senate elections occurred in the middle of Harry S. Truman's second term as president. The 32 seats of Class 3 were contested in regular elections, and four special elections were held to fill vacancies. As with most 20th-century second-term midterms, the party not holding the presidency made significant gains. The Republican opposition made a net gain of five seats, taking advantage of the Democratic administration's declining popularity during the Cold War and the aftermath of the Recession of 1949. The Democrats held a narrow 49-to-47-seat majority after the election. This was the first time since 1932 that the Senate majority leader lost his seat, and the only instance of the majority leader losing his seat while his party retained the majority.