The 1954 Prestwick air disaster occurred in the early morning of Christmas Day, 1954. A British Overseas Airways Corporation Boeing 377 Stratocruiser crashed on landing at Prestwick Airport, Scotland; 28 of the 36 on board were killed.

The Boeing 377 Stratocruiser was a large long-range airliner developed from the C-97 Stratofreighter military transport, itself a derivative of the B-29 Superfortress. The Stratocruiser's first flight was on July 8, 1947. Its design was advanced for its day; its relatively innovative features included two passenger decks and a pressurized cabin. It could carry up to 100 passengers on the main deck plus 14 in the lower deck lounge; typical seating was for 63 or 84 passengers or 28 berthed and five seated passengers.