The 1954 Prestwick air disaster occurred in the early morning of Christmas Day, 1954. A British Overseas Airways Corporation Boeing 377 Stratocruiser crashed on landing at Prestwick Airport, Scotland; 28 of the 36 on board were killed.

Glasgow Prestwick Airport, commonly referred to as Prestwick Airport, is an international airport serving the west of Scotland, situated one nautical mile northeast of the town of Prestwick Scotland, and 32 miles southwest of Glasgow, Scotland. It is the less busy of the two airports serving the western part of Scotland's Central Belt, after Glasgow Airport in Renfrewshire, within the Greater Glasgow conurbation. The airport serves the urban cluster surrounding Ayr, including Kilmarnock, Irvine, Ardrossan, Troon, Saltcoats, Stevenston, Kilwinning, and Prestwick itself.