The 1958 United States Senate elections were elections for the United States Senate which occurred in the middle of President Dwight D. Eisenhower's second term. Thirty-two seats of Class 1 were contested in regular elections, the new state of Alaska held its first Senate elections for its Class 2 and 3 seats, and two special elections were held to fill vacancies.

William Stuart Symington III was an American businessman and Democratic politician from Missouri. He served as the first Secretary of the Air Force from 1947 to 1950 and was a United States Senator from Missouri from 1953 to 1976.