The 45th International 500-Mile Sweepstakes was held at the Indianapolis Motor Speedway in Speedway, Indiana on Tuesday, May 30, 1961. For the first time since 1949, the Indianapolis 500 was not recognized on the World Championship calendar. The race celebrated the 50th anniversary of the first Indy 500 in 1911.

The Indianapolis Motor Speedway is a motor racing circuit located in Speedway, Indiana, an enclave suburb of Indianapolis, Indiana. It is the home of the Indianapolis 500 and the Brickyard 400 and formerly the home of the United States Grand Prix and Indianapolis motorcycle Grand Prix. It is located six miles (9.7 km) west of Downtown Indianapolis.