The 1962 United States Senate election in South Dakota took place on November 6, 1962. Incumbent Republican Senator Francis H. Case ran for re-election to a third term. He won the Republican primary against Attorney General A. C. Miller, but shortly after the primary, died. The Republican State Central Committee named Lieutenant Governor Joseph H. Bottum as Case's replacement on the ballot, and Governor Archie Gubbrud appointed Bottum to fill the vacancy caused by Case's death. In the general election, Bottum was opposed by Democratic nominee George McGovern, the Director of Food for Peace and the former U.S. Congressman from South Dakota's 1st congressional district. The contest between Bottum and McGovern was quite close, with McGovern narrowly defeating him for election by just 597 votes, making him the first Democrat to win a Senate election in South Dakota since William J. Bulow's win in 1936.

Francis Higbee Case was an American journalist and politician who served for 25 years as a member of the United States Congress from South Dakota. He was a Republican.