The 1965 San Francisco Giants season was the Giants' 83rd year in Major League Baseball, their eighth year in San Francisco since their move from New York following the 1957 season, and their sixth at Candlestick Park. The team finished in second place in the National League with a 95–67 record, 2 games behind the Los Angeles Dodgers.

The 1965 Los Angeles Dodgers finished the regular-season with a 97–65 record, which earned them the NL pennant by two games over their arch-rivals, the San Francisco Giants. The Dodgers went on to win the World Series in seven games over the Minnesota Twins.