The 1968 United States Senate elections were elections for the United States Senate. Held on November 5, the 34 seats of Class 3 were contested in regular elections. They coincided with the presidential election of the same year. The Republicans picked up five net seats in the Senate. This saw Republicans win a Senate seat in Florida for the first time since Reconstruction.

Elmer Edwin Rasmuson was an American banker, philanthropist and politician in the territory and state of Alaska. He led the family business, National Bank of Alaska, for many decades as president and later chairman. He also served as Mayor of Anchorage from 1964 to 1967 and was the Republican nominee for United States Senator from Alaska in the 1968 election, losing the general election to Mike Gravel.