The 1972 United States Senate election in Kentucky took place on November 7, 1972. Incumbent Republican Senator John Sherman Cooper retired, and Democratic State Senator Walter Dee Huddleston narrowly won the open seat over former Republican Governor Louie Nunn.

Louie Broady Nunn was an American politician who served as the 52nd governor of Kentucky. Elected in 1967, he was the only Republican to hold the office between the end of Simeon Willis's term in 1947 and the election of Ernie Fletcher in 2003.