The 1976 Guatemala earthquake struck on February 4 at 03:01:43 local time with a moment magnitude of 7.5. The shock was centered on the Motagua Fault, about 160 km northeast of Guatemala City at a depth of 5 kilometers (3.1 mi) near the town of Los Amates in the department of Izabal.

The Motagua Fault is a major, active left lateral-moving transform fault which cuts across Guatemala. It forms part of the tectonic boundary between the North American Plate and the Caribbean Plate. It is considered the onshore continuation of the Swan Islands Transform Fault and Cayman trench, which run under the Caribbean Sea. Its western end appears not to continue further than its surface trace, where it is covered by Cenozoic volcanics.