The 1978 Copa Libertadores finals was the final two-legged tie to determine the 1978 Copa Libertadores champion. It was contested by Argentine club Boca Juniors and Colombian club Deportivo Cali. The first leg of the tie was played on November 23 at Deportivo Cali' home field, with the second leg played on November 28 at Boca Juniors'. It was Deportivo Cali 1st Copa Libertadores finals and 3rd finals for Boca Juniors.

Asociación Deportivo Cali, best known as Deportivo Cali, is a Colombian sports club based in Cali, most notable for its football team, which currently competes in the Categoría Primera A.