The 1980 Indian general election in Tamil Nadu saw elections for all 39 Lok Sabha seats in the state. The result was a landslide victory for the Indian National Congress (Indira) and its ally Dravida Munnetra Kazhagam, who won 37 out of 39 seats. Many observers considered it an upset defeat for the ruling state party, All India Anna Dravida Munnetra Kazhagam, and its general secretary M. G. Ramachandran, which only won 2 seats—Gobichettipalayam and Sivakasi. Prior to the election, INC leader Indira Gandhi had formed an alliance with the DMK, resulting in an important part of her victory in the nationwide election that returned her to the office of Prime Minister of India.

The All India Anna Dravida Munnetra Kazhagam is an Indian regional political party with great influence in the state of Tamil Nadu and the union territory of Puducherry. It is a Dravidian party founded by the former chief minister of Tamil Nadu M. G. Ramachandran (M.G.R.) at Madurai on 17 October 1972 as a breakaway faction from the Dravida Munnetra Kazhagam after M. Karunanidhi expelled him from the party for demanding an account as the party treasurer. The party is adhering to the policy of socialism and secularism based on the principles of C. N. Annadurai (Anna) collectively coined as Annaism by M.G.R. The party has won a seven-time majority in the Tamil Nadu Legislative Assembly and has emerged as the most successful political outfit in the state's history. It is currently the main opposition party in the Tamil Nadu Legislative Assembly.