The 1992 Republican National Convention was held in the Astrodome in Houston, Texas, from August 17 to August 20, 1992. The convention nominated President George H. W. Bush and Vice President Dan Quayle for reelection. It was Bush's fourth consecutive appearance as a candidate on a major party ticket; only Bush and Franklin D. Roosevelt have been nominated on four consecutive presidential tickets. Richard Nixon and Roosevelt were nominated five times, but not consecutively.

The NRG Astrodome, formerly and also known as the Houston Astrodome or simply the Astrodome, was the world's first multi-purpose, domed sports stadium, located in Houston, Texas, United States. It sat around 50,000 fans, with a record attendance of 68,266 set by George Strait in 2002.