The 1994 United States Senate election in Michigan was held November 8, 1994. Incumbent Democratic U.S. Senator Don Riegle decided to retire and not run for re-election. Republican Spencer Abraham won the open seat, becoming the only Republican to win a U.S. Senate race in Michigan since Robert P. Griffin in 1972 and the first to win the state's Class I seat since Charles E. Potter in 1952.

Edward Spencer Abraham is an American attorney, author, and politician who served as the 10th United States Secretary of Energy from 2001 to 2005, under President George W. Bush. A member of the Republican Party, he previously served as a United States Senator from Michigan from 1995 to 2001. Abraham is one of the founders of the Federalist Society, and a co-founder of the Harvard Journal of Law and Public Policy. As of 2023, he remains the last Republican to serve as a U.S. senator from Michigan.