The play-off first legs were played on 14–16 November 2003, while the second legs were played on 18–19 November 2003. Winners of play-off round qualified to the championship played following year in May and June, where Germany was chosen to host the fixtures. For the draw of the play-offs, every of the six best runners-up were drawn against one of the six best group winners of another group with the runners-up playing their first match at home; the other group-winners were drawn each other. Serbia and Montenegro won 5–4 on aggregate Germany won 2–1 on aggregate Croatia won 2–1 on aggregate 3–3 on aggregate, Portugal won 4–1 on penalties. 3–3 on aggregate, Switzerland won 4–3 on penalties. Belarus won 5–1 on aggregate 1–1 on aggregate, Italy won on away goals rule. Sweden won 3–1 on aggregate Play-offs at UEFA.com
Kanoon Apna Apna is a 1989 Hindi action-drama film starring Dilip Kumar, Sanjay Dutt and Nutan. It was a box office hit, earning 4 Crore Net in 1989; the film, did not live up to the expectations set by Vidhaata that starred both Dilip Kumar and Sanjay Dutt. The film was a remake of Telugu film Collector Gari Abbai; the Collector of Anokhapur, Jagatpratap Singh is a stickler for order. However, his son, Ravi believes that sometimes illegal means may be adopted in order to assert control; this causes conflict between the two. Bhushannath'Dharmendra' Bhadbhole is a corrupt Minister of Fisheries, his son and Kabza Kanhaiyalal rape and kill Jagatpratap's maid/servant and kill Ravi's friend. They are acquitted. Ravi decides to give these criminals the punishment; as Ravi knows this will cause a conflict with his father, he decides to leave home. He becomes a police inspector; this does not heal the father-son bond. After deliberating on the statement that "the law is for human beings but not for monsters", the father agrees to join his son in his fight against the corrupt minister.
Dilip Kumar as Collector Jagatpratap Singh Nutan as Mrs. Lakshmi Singh Sanjay Dutt as Ravi Kumar Singh Madhuri Dixit as Bharati Kader Khan as Bhushannath'Dharmendra' Bhadbhole Gulshan Grover as Kailash Bhadbhole Anupam Kher as Kabza Kanhaiyalal Satyendra Kapoor as Editor Ramprasad Tej Sapru as Prakash K. Kanhaiyalal Mayur Verma as Satyen Raza Murad as Dr. Mathur Jayshree Gadkar as College Principal Disco Shanti as Item Number The soundtrack was written by Indeevar and composed by Bappi Lahiri. Kanoon Apna Apna on IMDb
The presidency of Chester A. Arthur began on September 19, 1881, when Arthur became the 21st President of the United States upon the assassination and death of President James A. Garfield, ended on March 4, 1885. Arthur, a Republican, had been Vice President of the United States for only 199 days when he succeeded to the presidency. In ill health and lacking the full support of his party by the end of his term, Arthur made only a token effort for the Republican nomination in the 1884 presidential election, he was succeeded by Democrat Grover Cleveland. Garfield chose Arthur as his running mate in the 1880 United States presidential election due to the latter's association with the Republican Party's Stalwart faction, Arthur struggled to overcome his reputation as a New York City machine politician, he embraced the cause of U. S. Civil Service Reform, his advocacy and enforcement of the Pendleton Civil Service Reform Act became the centerpiece of his administration. Though patronage remained a powerful force in politics, the Pendleton Act laid the foundations for a professional civil service that would emerge in subsequent decades.
Facing a budget surplus, Arthur signed the Tariff of 1883. He vetoed the Rivers and Harbors Act, an act that would have appropriated federal funds in a manner he thought excessive, oversaw a building program for the United States Navy. After the Supreme Court struck down the Civil Rights Act of 1875, Arthur favored new civil rights legislation to protect African-Americans, but was unable to win passage of a new bill. In foreign policy, Arthur pursued closer economic and political relations with Latin America, but many of his proposed trade agreements were defeated in the United States Senate; the 1884 Republican National Convention passed over Arthur in favor of James G. Blaine, but Cleveland defeated Blaine in the 1884 presidential election. Although Arthur's failing health and political temperament combined to make his administration less active than a modern presidency, he earned praise among contemporaries for his solid performance in office. Journalist Alexander McClure wrote, "No man entered the presidency so profoundly and distrusted as Chester Alan Arthur, no one retired... more respected, alike by political friend and foe."
Since his death, Arthur's reputation has faded from the public consciousness. Although some have praised his flexibility and willingness to embrace reform, present-day historians and scholars rank him as a below-average president. After President Rutherford B. Hayes declined to seek re-election in 1880, several candidates vied for the presidential nomination at the 1880 Republican National Convention; the convention dead-locked between supporters of former President Ulysses S. Grant and Senator James G. Blaine, resulting in the nomination of a dark horse candidate, James A. Garfield. Hoping to unite the Republican Party behind his candidacy, Garfield decided to select a follower of New York Senator Roscoe Conkling, a leader of the party's Stalwart faction, as his running mate. Garfield settled on Arthur, a former Collector of the Port of New York, allied with Conkling; the Garfield-Arthur ticket won the 1880 presidential election, but after taking office, Garfield clashed with Conkling over appointments and other issues.
Arthur's continued loyalty to Conkling marginalized him within the Garfield administration and, after the Senate went into recess in May 1881, Arthur returned to his home state of New York. On July 2, 1881, Arthur learned; the shooter, Charles J. Guiteau, was a deranged office-seeker who believed that Garfield's successor would appoint him to a patronage job. Though he had known Guiteau, Arthur had to allay suspicions that he had been behind the assassination, he was reluctant to be seen acting as president while Garfield lived, in the months after the shooting, with Garfield near death and Arthur still in New York, there was a void of authority in the executive office. Many worried about the prospect of an Arthur presidency. Garfield died on September 19, Judge John R. Brady of the New York Supreme Court administered the oath of office to Arthur in the latter's New York City home at 2:15 a.m. on September 20. Before leaving New York, Arthur ensured the presidential line of succession by preparing and mailing to the White House a proclamation calling for a Senate special session, thus ensuring that the Senate could select a president pro tempore, who would be first in the presidential line of succession.
On September 22, Arthur re-took the oath of office, this time before Chief Justice Morrison R. Waite, he took this step to ensure procedural compliance. Arthur ordered a remodeling of the White House and took up residence at the home of Senator John P. Jones until December 1881, when he moved into the White House; as Arthur was a widower, his sister, Mary Arthur McElroy, served as the de facto First Lady of the United States. Arthur took office over a growing country that maintained a budget surplus and peaceful relations with the great powers of the day. Arthur came into conflict with Garfield's cabinet, most of whom represented opposing factions within the party. At the same time, he distanced himself from Conkling, he sought to appoint officials who were well-regarded by both reformers and party loyalists. Arthur asked Garfield's cabinet members to remain until December 1881, when Congre
David Madden is an Australian entrepreneur associated with progressive causes. He is a co-founder of GetUp! A web-based political movement, Avaaz, a global advocacy movement. Madden grew up in Canberra and served as an Army officer before studying Arts and Law at the University of New South Wales in Sydney. Madden served as president of the University of New South Wales Student Guild. After winning the University Medal in History, Madden was awarded Fulbright and Frank Knox scholarships to study at the Kennedy School of Government at Harvard University, where he completed his master's degree in public policy, he met Jeremy Heimans, with whom he would co-found GetUp and Avaaz, waiting for a scholarship interview panel while studying at Harvard. Madden and Heimans became involved in the Harvard Living Wage campaign in 2001, Madden credits it as their first political collaboration. Madden has worked for the World Bank in Timor Leste, for the United Nations in Indonesia, he is the co-author of Imagining Australia: Ideas for Our Future, with economist turned federal MP Andrew Leigh, Macgregor Duncan, Peter Tynan.
In 2004, Madden was one of the founders of Win Back Respect, a web-based campaign against the foreign policy of United States President George W. Bush; the following year, together with Jeremy Heimans, he co-founded GetUp, a similar campaign against the re-elected Howard government in Australia, inspired by what he had seen with MoveOn in the United States. In 2006, Madden and Heimans were credited by the World E-Government Forum as being among the top 10 people involved in changing the world of the internet and politics, he subsequently stepped back from the day-to-day operations of GetUp, but maintained a position on the organisation's board. Madden and Heimans subsequently ran a political consultancy in the United States, before co-founding international campaigning outfit Avaaz. In the private sector, Madden is credited with the creation and marketing of TwitterPeek, the world's only mobile Twitter-only device. CNN named it as one of their top 10 tech fails of 2009. GetUp
PRC2 is one of the two classes of polycomb-group proteins or. The other component of this group of proteins is PRC1; this complex has histone methyltransferase activity and trimethylates histone H3 on lysine 27, a mark of transcriptionally silent chromatin. PRC2 is required for initial targeting of genomic region to be silenced, while PRC1 is required for stabilizing this silencing and underlies cellular memory of silenced region after cellular differentiation. PRC1 mono-ubiquitinates histone H2A on lysine 119; these proteins are required for long term epigenetic silencing of chromatin and have an important role in stem cell differentiation and early embryonic development. PRC2 are present in most multicellular organisms; the mouse PRC2 has four subunits: Suz12, Ezh1 or Ezh2 and RbAp48. PRC2 can bind to repress neighboring nucleosomes, thus spreading the repression. PRC2 has a role in X chromosome inactivation, in maintenance of stem cell fate, in imprinting. Aberrant expression of PRC2 has been observed in cancer.
Both loss and gain-of-function mutations in PRC2 components have been identified in various human cancers, suggesting complex roles of these components in malignancy. Polycomb group genes directly and indirectly regulate the DNA damage response which acts as an anti-cancer barrier; the PRC2 complex appears to be present at sites of DNA double-strand breaks where it promotes repair of such breaks by non-homologous end joining. The PRC2 is evolutionarily conserved, has been found in mammals and plants. In Arabidopsis thaliana, a plant model organism, several variants of the core subunits have been identified. Homologs of the Suz12 subunit are: Embryonic flower 2, reduced vernalization response 2, fertilization independent seed 2. There is fertilization independent endosperm. Three Ezh1/Ezh2 homologs, curly leaf, swinger and one RbAp48 homolog, multicopy suppressor of IRA1. Epigenetics