The 1998 United States Senate election in South Carolina was held November 3, 1998. Incumbent Senator Fritz Hollings won reelection to his seventh term. As of 2024, this is the last time that a Democrat has won a U.S. Senate election in South Carolina. This is also the last time the Democratic nominee for this Senate seat was a white man, as in future elections Democrats would either nominate a woman and/or a person of color.

Ernest Frederick "Fritz" Hollings was an American politician who served as a United States senator from South Carolina from 1966 to 2005. A conservative Democrat, he was also the 106th governor of South Carolina, the 77th lieutenant governor of South Carolina, and a member of the South Carolina House of Representatives. He served alongside Democrat-turned-Republican Senator Strom Thurmond for 36 years, making them the longest-serving duo in U.S. Senate history. At the time of his death, he was the oldest living former U.S. senator.