The 1999 Indian general election polls in Tamil Nadu were held for 39 seats in the state. The result was a victory for the National Democratic Alliance (NDA) which won 26 seats. After leaving the NDA, All India Anna Dravida Munnetra Kazhagam, hoped to create some damage, but ended up losing 8 seats, compared to the 1998 Lok Sabha elections. This is also the first time that Dravida Munnetra Kazhagam, allied with the Bharatiya Janata Party, helping them have power at the national level for the next 5 years with the NDA, before they joined the UPA. The NDA, ended up losing 3 seats, compared to the election the year before, due to AIADMK leaving the NDA, but the seats were made up, because DMK left the united front and joined the NDA.

General elections were held in India between 5 September and 3 October 1999, a few months after the Kargil War. Results were announced on 6 October 1999.