The 1999 NFL draft was the procedure by which National Football League teams selected amateur college football players. It is officially known as the NFL Annual Player Selection Meeting. The draft was held April 17–18, 1999, at the Theater at Madison Square Garden in New York City, New York. The league also held a supplemental draft after the regular draft and before the regular season.

The 1999 NFL season was the 80th regular season of the National Football League (NFL). The Cleveland Browns returned to the field for the first time since the 1995 season, while the Tennessee Oilers changed their name to "Tennessee Titans", with the league retiring the name "Oilers".