The 1st Grande Prêmio Cinema Brasil ceremony, presented by the Ministry of Culture of Brazil, honored the best audiovisual productions of 1999. It took place on February 12, 2000, at the Palácio Quitandinha in the city of Petrópolis, Rio de Janeiro. During the ceremony, the Ministry of Culture presented the Grande Prêmio Cinema Brasil in 17 categories. The ceremony, televised by TV Cultura and Televisão Educativa, was directed by José Possi Neto and hosted by actress Regina Casé.

The Grande Prêmio do Cinema Brasileiro, more popularly known as the Grande Otelo, is a Brazilian film award given annually by the Brazilian Academy of Cinema. It was established in 2000 as the Grande Prêmio Cinema Brasil by the Ministry of Culture of Brazil that presented it in 2000 and 2001. In 2002, the newly established Academia Brasileira de Cinema took on the role of delivering the award which was then renamed to Grande Prêmio do Cinema Brasileiro.