The 1st Oregon Infantry Regiment was an American Civil War era military regiment recruited in Oregon for the Union Army. The regiment was formed in November 1864. At full strength, it was composed of ten companies of foot soldiers. The regiment was used to guard trade routes and escorted immigrant wagon trains from Fort Boise to the Willamette Valley. Its troops were used to pursue and suppress Native American raiders in eastern Oregon and the Idaho Territory. Several detachments accompanied survey parties and built roads in central and southern Oregon. The regiment's last company was mustered out of service in July 1867.

John Miller Drake was a Union Army officer in the 1st Oregon Cavalry and the 1st Oregon Infantry regiments during the American Civil War. He eventually reached the rank of lieutenant colonel. He led one of the first campaigns to respond to the threat Chief Paulina posed to settlers and rival Indians in central Oregon. Later he was a purchasing agent for the Oregon Railway and Navigation Company.