The 1st Regiment "Granatieri di Sardegna" is an active unit of the Italian Army based in Rome in Lazio. The regiment is part of the army's infantry arm's Granatieri (Grenadiers) speciality and assigned to the Mechanized Brigade "Granatieri di Sardegna". Formed in 1659 the regiment is the currently oldest active unit of the Italian Army and the most senior regiment in the Italian Army's infantry order of precedence. Together with its sister the regiment, the 2nd Regiment "Granatieri di Sardegna", the regiment is the guard regiment of Rome.

The Mechanized Brigade "Granatieri di Sardegna" is a mechanized infantry brigade of the Italian Army, based in Rome and central Italy. The brigade fields one of the oldest regiments of the Army and is one of the guard regiments of the President of Italy. The name of the unit dates back to the Kingdom of Sardinia and not the eponymous Mediterranean island of Sardinia. The brigade is part of the Division "Acqui".