The 1st West Virginia Cavalry Regiment served in the Union Army during the American Civil War. Although it started slowly, it became one of the most active and effective of the West Virginia Civil War regiments—and had 14 Medal of Honor recipients, the most for any West Virginia regiment during the war. It was originally called the 1st Virginia Cavalry, not to be confused with the Confederate 1st Virginia Cavalry. Some reports added "Union," "Loyal" or "West" when identifying this regiment. After the Unionist state of West Virginia was officially admitted to the Union in 1863, the regiment became the 1st West Virginia Cavalry Regiment. The National Park Service identifies it as the 1st Regiment, West Virginia Cavalry.

Henry Capehart was a surgeon and officer in the U.S. Cavalry during the American Civil War. He received the Medal of Honor for saving the life of a drowning soldier while under fire at Greenbrier River, West Virginia, on May 22, 1864.